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Retatrutide, the triple agonist targeting GLP-1, GIP, and glucagon receptors, shows approximately 24% weight loss in phase 2 trials

References Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al

Such genetic alterations were all reverted by low doses if IGF-1 replacement therapy for only 10 days

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Oral administration significantly reduces lipogenic activity and increases lipolytic activity in adipose tissue, with concurrent increases in fat and glucose oxidation and elevated energy expenditure

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