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The Patient-Reported Outcome Measurement Information System (PROMIS-10), which measures a combination of physical, mental, and social determinants of health [55], as well as the NeuroQoL-fatigue, an 89 question survey about fatigue [56], correlate with ALSFRS-R scores [57] and are being incorporated more consistently across neurology trials, but are not specific to ALS

36 Yet, these compensatory mechanisms are often inadequate during high-speed or unpredictable movements, leading to a heightened risk of instability

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This article will discuss the unique interplay between our hormones and cognition and how BHRT can help

For instance, 5-methoxytryptophan (5-MTP), an endogenous tryptophan metabolite, has been shown to possess anti-inflammatory properties and to inhibit cell proliferation and migration