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Instead, these variants are more likely to engage in heterotypic interactions with cellular proteins and membrane organelles, which may explain why Shahmoradian et al

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Dopaminergic neurons in the SN are particularly sensitive to oxidative stress (Szirki et al., 1998) due to their elevated levels of pro-oxidant iron, which facilitates ROS production by reducing oxygen, and their low levels of glutathione, a crucial antioxidant in cellular metabolism (Sian-Hlsmann et al., 2011)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 115.Fredrickson J., Serkova N.J., Wyatt S.K., Carano R.A., Pirzkall A., Rhee I., Rosen L.S., Bessudo A., Weekes C., de Crespigny A

Mast Cell Activation Syndrome (MCAS) is a complex and often misunderstood condition