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Total cumulated nucleus-associated DAPI and PI fluorescence was assessed in a blinded fashion by apply an automated detection method (cellSens Dimension 1.18, Olympus, Count and Measure tool)

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A meta-analysis of seven studies including 1,757 participants with type 2 diabetes found that SGLT2 inhibitor therapy in combination with blood pressure medications (known as renin-angiotensin system blockers) was well-tolerated and resulted in greater improvement in blood pressure, glucose control, body weight, and indices of kidney function compared with the blood pressure drugs alone (Tian 2021)