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Experimental studies in rodents and other small mammals consistently demonstrate that disruptions to normal light-dark cycles (e.g., via phase shifts, continuous light or darkness, or dim LAN) can impair various components of the immune system, including natural killer (NK) cell activity, cytokine production, balance in white blood cell populations, and immune responses to pathogens, tumors, or injury 87

[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Wu, F

Epidermal fatty acid binding protein (E-FABP) expression in nave CD8+ T cells facilitates linoleic acid transport via mitochondria and its incorporation into cardiolipin, which induces lipid peroxidation and mitochondrial ROS production, leading to apoptosis and reduced TNF production [84]

This switch affects nearby neurons where the surge of lactate creates a rapid metabolic response in the neurons, with incoming lactate acting as an energy substrate, and depolarizing them to increase overall network excitability (Figure 2)

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They do not represent or reflect the official policy, position, or views of the Australian Defence Force, the Commonwealth of Australia, or any organisations or clinics the author has worked for, past or present