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With respect to the underlying mechanism, Mn imbalance promotes oxidative stress by impairing mitochondrial function and promoting excessive ROS production, which can directly exacerbate an underlying metabolic syndrome and its associated pathologies 227,228

This makes it a valuable supplement for supporting energy metabolism, especially during periods of physical activity

By expanding the surface volume and fostering the prospect for MOF-ligand interaction, MOF-based surfaces strengthen the long-term viability and selectivity of traditional MOFs, while conjugated films substantially broaden the area of active functional groups

Parvin MS, Chlebek J, Holkov A, Catapano MC, Lomozov Z, Mackov K, Mladnka P (2022) Interactions of isoquinoline alkaloids with transition metals iron and copper

N Engl J Med 366(4):348359 Provenzano R et al (2009) Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients

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