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Studies have shown that when stem cells are co-cultured in an IDD-like environment in vivo or in vitro, they can produce anti-inflammatory cytokines, anti-metabolic mediators, and growth factors, thus modulating the immune response [33,34,35] (Fig

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De Oliveira DP, Garcia EF, De Oliveira MA, Candido LCM, Coelho FM, Costa VV, et al

Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling

GABA in the glia can act as a metabolic substrate and be finally re-converted to glutamine, transferred to neurons, and converted to glutamate, which re-enters the GABA shunt

Broccoli sprouts are concentrated sources of sulforaphane, a type of isothiocyanate