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Thymosin beta-4 functions as a major actin-sequestering protein, binding to monomeric G-actin and preventing its polymerization into filamentous F-actin

In a gene detecting research, mutations on G367A and V71I of isocitrate dehydrogenase 1 (IDH1), which converts -KG to 2-hydroxyglutarate are discovered in several cases of different types of TC [184], but the regulating mechanism still needs exploration