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0.5 mg (500 mcg) per administration the dose that met the Phase 2b endpoint

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For IBS, IBD, gastritis, or ulcers, protocols typically use oral administration at 0.5 to 1 mg daily to maximize local gastrointestinal exposure

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Stress elevates cortisol levels overnight, which can increase stomach acid production and worsen IBS symptoms, with pain often most severe in the morning when cortisol naturally peaks

The success of fecal microbiota transplantation is most strongly linked to the method of administration, especially when combining both upper and lower gastrointestinal applications [172]