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Gut microbes are the true first line of defense against toxins The Gut as a Detoxification Organ You may recall learning that there are three primary phases of detoxification: Phase I: cytochrome P450 and other enzymes introduce polar groups via oxidation, reduction, or hydrolysis Phase II: conjugation via processes like methylation, acetylation, or sulfonation Phase III: further modification and excretion The Gut as Phase 0.5 Detoxification Phase I cytochrome P450 is often referred to as the first line of defense against environmental toxins

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