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In REDEFINE 1, the combination produced larger average weight loss than either compound alone 20.4% with CagriSema versus 14.9% with semaglutide alone and 11.5% with cagrilintide alone, all under the treatment-policy estimand

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If the desired results are not seen after 3-6 months, or if the patient cannot tolerate the medication, discontinuation or alternative treatments may be considered