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Antimicrobial peptides are essential components of the host defense system and play a regulatory role in the composition of the gut microbiota

Endocrinology 140 , 29242927 (1999)

A 2015 review in Cell Metabolism demonstrating that NAD+ precursor supplementation reverses mitochondrial dysfunction in aged muscle and restores metabolic function reinforced the mechanistic rationale for NAD+ as a longevity therapy

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However, when looking into the details of the dataset, it appeared that MAGE-A4-TCB and the DP47 TCB control antibody induced cytokine release and proliferation of T cells in co-cultures with neonatal melanocytes ( Figure 11A ), thereby suggesting that the CD3 binder itself may trigger immune activation in vitro