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A recent study also demonstrated mislocalization of APE1 from the nucleus to the cytoplasm as a possible trigger of oxidative DNA damage in spinal motor neurons expressing mutant SOD1 G93A , despite upregulation of multiple DNA repair enzymes, suggesting that restricted localization of APE1 could inhibit redox homeostasis (Li J

Evening Administration (if applicable): If your research protocol involves a second daily dose, take it at least 2-3 hours after your last meal of the day, ideally right before bed

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