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Twenty-seven patients received acetyl-l-carnitine at a dose of 500 mg twice daily for 10 days intramuscularly followed by the oral intake of 500 mg for 50 days (arm A)

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In addition, rats with sepsis had a 70% reduction in PDHC activity and decreased acetyl-CoA production in skeletal muscle cells, resulting in hypoxia and dysfunction in skeletal muscle cells (Figure 2) (65)