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Meanwhile, knockdown of REST significantly increased GSH synthesis, restored GPX4 expression, and ultimately attenuated ferroptosis, which had an additive effect on the ferroptosis inhibitors Fer-1 and DFO

HT-1080 cells were the generous gift of Professor Chu Wang (Peking University, China)

Cel Mol Med 23 (12), 81398150

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Intracellular GSH is further lowered by taking high dose TTFD, and there is not enough enzyme activity to recycle it back Oxidative stress is made worse In the above scenario, taking a high dose of TTFD may not be appropriate

The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome