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Targeting Endothelial and Myocardial Dysfunction With Tetrahydrobiopterin

& Vierling, E

Nature 519 , 223228 (2015)

In HGN, pathways such as phenylpropanoid biosynthesis, phenylalanine metabolism, isoflavonoid biosynthesis, fructose and mannose metabolism and inositol phosphate metabolisms were upregulated, while phosphonate metabolism, pyrimidine metabolism, monoterpenoid biosynthesis, glycerolipid metabolism, and amino sugar and nucleotide sugar metabolism were downregulated (Fig

This stress typically occurs when the animal is exposed to a variety of infectious agents as a result of transportation and handling