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1,22 Hyperlipidemia increases the adjusted likelihood of developing PAD by 10% for every 10 mg/dL rise in total cholesterol (to convert to mmol/L, multiply by 0.0259)

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Figure 4 Myocardial hypertrophy and fibrosis TMAO significantly increased the mRNA and protein levels of the hypertrophic markers atrial natriuretic peptide (ANP) and -myosin heavy chain (-MHC), causing myocardial hypertrophy and fibrosis (94)

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It happens in the mitochondria the small energy-producing parts found in each cell of the body