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Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols

10.1016/j.antiviral.2012.09.010 19 CuiL.LiZ.ChangX.CongG.HaoL

1 Introduction 1.1 Mitochondrial function and dynamics Mitochondria are membrane-enclosed organelles that contain their own DNA, mitochondrial DNA (mtDNA), and generate most of the cells energy in the form of ATP, using glucose, fatty acids and amino acids as energy substrates

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The -glucan, lentinan, is a bioactive compound produced by the macrofungus, Lentinus edodes, and has been found to have potential in improving the side effects of broad-spectrum antibiotic consumption

309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig