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3.4 Cytokines and signal pathways Reduced cytokine synthesis, which inhibits T cell and macrophage activity, may be linked to the pathophysiology of CD

Oligodendrocytes appear to be particularly vulnerable to reactive oxygen species (ROS) and cytokines, such as tumor necrosis factor- (TNF), which induce cell death and prevent the differentiation of oligodendrocyte progenitor cells (OPCs)