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Maneiros team employed copper-free click chemistry (SPAAC) to conjugate the BRD4 degrader ARV-771 to trastuzumab, yielding a HER2-targeting DAC that exhibited selective BRD4 degradation and robust stability in HER2 + cells [217]

A total of 170 patients were included in the study (72 in Group A and 98 in Group B)

Wei J, Zhen YZ, Cui J, He FL, Shen T, Hu G, et al

Though there was no statistically significant difference in caregiver-rated Social Responsiveness Scale (SRS) in the group as a whole, there was statistically significant benefit in a subgroup of patients between ages 3-5

Key ingredients : vitamin C

10.1016/j.jep.2025.119746 12 FurmanB