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Expect one to three days of increased nausea, possibly some digestive changes , and maybe some fatigue

Locasale JW (2013) Serine, glycine and one-carbon units: cancer metabolism in full circle

10.3390/ijms21134620 165 ParkS

10.1016/j.cmet.2021.12.004 74 SasakiK.BohnenbergerS.HayashiK.KunkelmannT.MuramatsuD.PhrakonkhamP.et al (2012a)

Tirzepatide users commonly report that high-fat foods cause the worst nausea and bloating, because the slowed gastric emptying means fat sits in the stomach longer