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Neuritic plaques are microscopic lesions in dendrites and terminal portions of axons

The researchers showed that blocking glutamine metabolism through JHU083 not only suppressed tumor cell metabolism but also mitigated the tumor microenvironment, which is hostile to the immune response due to its hypoxic, acidic, and nutrient-depleted conditions, unleashing the natural antitumor T cell response

Following extinction, tests for cue-induced reinstatement and spontaneous recovery were conducted

As well as general chaperone activity, PDI family members possess oxidoreductase activity, which mediates the formation of protein disulfide bonds by cysteine residues located within its active site