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We still recommend performing the Ames test when a test article is larger than MW = 1,400

compositions according to the invention having the above-described preferred dissolution profile, include compositions with any of the following features: first coating comprising HPMC (such as, e.g., Methocel LV), followed by a second coating (which is exterior to the first coating) which is a pH dependent enteric coating (such as, e.g., Eudragit L30 D-55, Eudragit L100, or Eudragit S100), wherein the first coating preferably has a coating thickness between 200 pm and 700 pm (more preferably between 300 and 600 pm)

Key benefits include: - Quantifies bone mineral density (BMD) at clinically relevant sites (spine, hip, forearm) - Identifies individual fracture risk before clinical events - Supports evidence-based interventions such as lifestyle modification, nutrition, and pharmacotherapy - Uses minimal radiation exposure - Offers a measurable tool for monitoring treatment efficacy Proactive bone health management is essential to prevent fractures, maintain function, and improve long-term quality of life

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, et al