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123 CD38 downregulates NAD + by converting NAD + to cyclic-ADP riboside, mobilizing intracellular or extracellular Ca+

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Docking studies with jr PPO1-wt revealed that the main driving force for the correct substrate orientation is the -stacking system established between the aromatic ring of the gatekeeper residue Phe260, the substrates aromatic ring and the imidazole group of the CuB coordinating His243 ( -stacking system: Phe260-substrate-His243) (Fig

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