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Potent therapeutic GLS inhibitors, such as bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) and its analogs such as CB-839, are being actively investigated in GLS-targeting studies [38, 54,55,56,57,58]

Liang et al., 2012)

The combination of Andrographis and curcumin exhibited a superior inhibitory effect against GPX4 and FSP1 to either drug alone

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1 Introduction Glaucoma, as one of the main causes of visual loss worldwide, is estimated to affect 76 million people aged 4080 and is expected to increase to 112 million by 2040 (1)