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doi: 10.1111/j.1360-0443.2005.001127.x

People with underlying medical disorders such as diabetes, cardiovascular disease, lung disease, or cancer are more prone to experience serious illness

It has also been suggested that propofol appears to exacerbate injury-induced apoptosis through the superinduction of the p75 neurotrophin receptor (p75NTR) and the increased pro-BDNF: mBDNF ratio, leading to a massive disruption of the homeostasis of pro-apoptotic/pro-survival neurotrophic factor signaling [107]