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Ferroptosis is a novel form of iron-dependent programmed cell death characterized by specific hallmarks, such as glutathione depletion, decreased glutathione peroxidase activity and the inability of lipid oxides to be processed through the glutathione peroxidase (GPX) pathway, which is catalyzed by GPX4

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In addition, simvastatin increased the expression of co-stimulatory molecules, production of IL-1 and IL-12p70, apoptosis, and autophagy in Mtb-infected monocytes (143)