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Under hypoxic conditions, AMPK cooperates with HIF-1 to enhance glycolytic capacity

Mechanisms of Action and Pharmacokinetics The DPP-4 Inhibitors increase the concentration of active incretin hormones, GLP-1, and glucose, which depends on insulinotropic polypeptide (GIP)

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It is important to keep in mind, however, that some of these substances may have pharmacological limitations, including the mechanism of drug action, administration route, tolerability, side effects, and proven efficacy, that should be considered before they could be approved for its use in this pathology