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Importantly, SHANK3 mutations have also been shown to disrupt inhibitory synapses: In mice, deletion of exon 9 results in decreased GABAergic transmission into the hippocampus and striatum because of inappropriate gephyrin clustering and GABA receptor trafficking [118],[119]

Shigetomi, E., Patel, S

Equine lysozyme 5.2

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PMID: 18556144

However, autophagy activity decreases with age, promoting the buildup of damaged components and increasing vulnerability to age-related diseases such as neurodegeneration, cancer, and metabolic disorders (Fig