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The study was approved by the Research Ethics Committee, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan (Ref

This suggests that the current recommendation for vitamin B12 is likely not high enough

Annu Rev Physiol

Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)