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Neurotrophic signalling peptides (P21 / P021): studied for BDNF-mimetic activity at the TrkB receptor

There are added interactions with systemic inflammatory status, redox balance, the NRF2/kelch-like ECH-associated protein 1 pathway, glycolipid metabolism or metal chelation

O.CiobicaA.MafteiR.GrabD.et al (2020)

We found that RES or NAC significantly restored cell morphology (Figure 6A), increased cell viability (Figure 6B), and reduced apoptosis caused by OA treatment (Figure 6C), but did not restore proliferation at a series of concentrations (Figure 6D

409,410 Repurposing Pentoxifylline Pentoxifylline (Pentopak, Pentoxil, or Trental) is a drug that reduces blood viscosity and improves blood flow

Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A