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Metabolite Toxicity Membrane damage Enzyme attachment to the cytoplasmic membranes of heart cells Disruption of ion transport across membranes Changes in the integrity of ion channels and transporters Activation of signaling pathways Activation of protein kinases Gene transcription Initiation of apoptosis Side Effects of LC and ALC Administration The administration of drugs like LC and ALC, through mechanisms that are not fully understood, results in the following effects: Preservation of metabolism Improvement of heart function under ischemic conditions In a study conducted in 2003, the administration of 5 and 0.5 mM concentrations of ALC and LC 10 minutes before inducing global ischemia (complete ischemia) did not prevent the occurrence of ventricular fibrillation in rats, but the 5 mM concentration reduced the infarct size

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ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia