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Abstract Background Fibromyalgia (FM) as a prototypical nociplastic pain condition displays a difficult therapeutic situation in many cases

Recent Phase 3 clinical trials have demonstrated exceptional results, with the REDEFINE program showing weight loss outcomes of up to 20.4% when combined with semaglutide, representing some of the most significant weight reduction results ever achieved in obesity research

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Although prolonged treatment with oral N-acetylcysteine (NAC) prevents acute exacerbations of chronic bronchitis, it remains controversial for the treatment of COPD (91, 103105)

Data exclusion and missing data For CRP values, one datapoint of 7.5 mg/L was excluded due to deviating more than four standard deviations from the samples mean

Wang DH, Li DC, Zhang GC, Wang CL, Wei GY (2019) Disruption of por1 gene in Candida utilis improves co-production of S-adenosylmethionine and glutathione