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In a mouse PD model, Mucuna pruriens seed extract (rich in natural LDOPA plus other constituents) was found to decrease levels of interleukin6 (IL6) and TGF1 in the brain, similar to pure levodopa [47]

TCM herbal therapies have been used traditionally to promote circulation, resolve blood stasis, and tonify the heart in these conditions

UC is a chronic disease characterized by generalized inflammation of the rectal and colonic mucosa [5]

These models are particularly relevant for studying myocardial reperfusion injury and coronary artery disease, as well as for exploring the pathophysiology of I/R injury in other organs such as the liver and kidney

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Indeed, erastin treatment leads to significant depletion of intracellular GSH, as detected using traditional biochemical methods and more advanced metabolomics analyses [6, 7, 28]