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Subsequently, JAKs phosphorylated Insulin receptor substrate 1 (IRS1) and 2 (IRS2) which evoked signaling through the PI3K/AKT pathway (Fig

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PPAR agonists also modulate immune responses and enhance antioxidant defenses, positioning them as promising therapies for neurological disorders including Alzheimers disease, Parkinsons disease and HIV-associated neurocognitive disorders (HAND) (160)