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ADHD drugs such as clonidine and guanfacine, as well as the dopamine agonist Pramipexole, were once touted as potential nootropics, only to be marred later by null findings when tested for cognitive enhancement in healthy individuals

This alters EC properties through the production of a broad spectrum of proteases and coagulation factors, which disrupt NVU cells and contribute to BBB dysfunction, leading to prolonged inflammation [211, 213,214,215]

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It also reduces oxidative stress, a key contributor to hearing loss, by increasing antioxidant defenses and scavenging harmful free radicals

In contrast, the Cagri-AMY 2 R-Gs complex was stable in the consensus AMYR conformation with stable TM interaction between RAMP2 and CTR, and the peptide maintained a bypass motif

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