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Over time, a substantial proportion of patients develop a progressive phase, typically 10 to 15 years after disease onset, characterized by gradual accumulation of disability and ongoing neurodegeneration that becomes less directly associated with the acute inflammatory activity [104]

Downregulation of RB1 and S18-2 was correlated with decreased expression of stemness-related genes, such as OCT-4, KLF-4, NANOG and c-MYC in human MSCs [66]

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