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Cells were incubated with C11-BODIPY (5 M) in 24-well plates for defined periods

doi: Givan GV, Diehl JJ

Nuclear translocation and transcription of antioxidant genes Upon dissociation, NRF2 translocates into the nucleus, where it binds to antioxidant response elements (AREs) located in the promoter regions of its target genes, thereby initiating their transcription

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Oral administration is simple, painless, and non-invasive , making it ideal for patients hesitant about self-injection

It is yet to be determined whether this process contributes to the induction of oxidative stress in tumors