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Baseline inflammatory status may also predict treatment responses, with patients exhibiting elevated inflammatory markers potentially experiencing greater benefits from GHK-Cu's anti-inflammatory effects

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So its a genetic is genetically influenced, epigenetics turn on but genetically stays on, you wont get these patients better by detoxifying them

A pooled analysis of gender and trauma-type effects on responsiveness to treatment of PTSD with venlafaxine extended release or placebo