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To test our hypothesis, we first detected GCLC expression and found that when NRF2 was knocked down, the inhibition of GCLC expression by ACTL6A KD was diminished

Regarding studies of potential treatments, N-acetylcysteine (NAC) is believed to exert therapeutic antioxidant effects as a substrate for glutathione synthesis

In particular, it has been proposed that CSF biopsy may be used to adapt radiotherapy should LMD not respond to other treatments [95]

Nicotinic acid was the first hypolipidemic agent shown to decrease the incidence of secondary myocardial infarction (MI) and reduce total mortality in MI patients

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Concurrently, it functions as an essential cofactor for prolyl hydroxylase and lysyl hydroxylase, enzymes critical for collagen biosynthesis (Nassar et al., 2025)