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Therefore, our research group implemented a bovine model comparing unsupplemented beef heifers to those receiving a Se-containing mineral supplement (VTM) to understand the impacts of early gestation supplementation on maternal and fetal outcomes (2833)

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Since storage additives are devoid of amino acids, elevation in intracellular amino acids is consistent with proteolysis (e.g., via proteasomal degradation), a phenomenon that is mechanistically linked to (extravascular) hemolysis 45

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Of note, GFAP is produced by activated astroglia that release ROS and pro-inflammatory mediators, creating a vicious cycle between oxidative stress and inflammation and hence playing a vital role in neuroinflammation with its subsequent neuronal apoptosis and hence neuronal damage (Colombo and Farina 2016)