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When stress increases cortisol, it has the ability to blunt GnRH pulses, but peptide signals can restore pulse frequency and amplitude, which supports appropriate FSH and LH release

PMID 8132480

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14:79 Larzelere MM, Jones GN (2008) Stress and health

Furthermore, iron sulfate supplementation had a stronger effect on the gut microbiota than electrolytic iron, indicating that ferrous iron was more readily utilized by the microbiota

Beyond individual clinicians reports, there are indications that the medical community is exploring stem cell therapy for EDS in a research setting