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Funding The author declares that no financial support was received for the research, authorship, and/or publication of this article

Makino SI, Shirata N, Oliva Trejo JA, Yamamoto-Nonaka K, Yamada H, Miyake T

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In clinical studies, treatment with recombinant IGF-1 improved renal function in patients with moderate renal insufficiency or end stage renal disease (ESRD), as evidenced by increased GFR, lower plasma creatinine and BUN levels, and enhanced inulin clearance