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Additionally, Oshiyama et al

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Toxicology and environmental impacts of hybrid nanomaterials This section critically evaluates the potential toxicology and environmental impacts of these hybrid nanomaterials themselves, including risks arising from metal-bio interfaces, to inform safe translation into clinical wound therapies

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Iron death, characterized by oxidative stress due to intracellular Fe2+ accumulation, leading to large amounts of ROS production, ultimately results in cell death (161) and contributes to various cardiovascular diseases including atherosclerosis, I/R injury, HF, myocardial infarction and adriamycin cardiomyopathy (162)