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Off-line HPLC fractionation For SICyLIA proteomic experiments, both IAM and dimethyl-modified protein digests were fractionated using reverse phase chromatography

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Nowadays we can understand that sex, age, race and ethnicity, in the context of socioeconomic status and lifestyle (tobacco, alcohol, education, physical exercise, unbalanced diet, etc.) impacts directly in its prevalence [7, 8, 10, 27 36]