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77,78 Chen et al discovered that CYP2J2 upregulation, in mice induced with high-fat diets, decreased the activation of the nuclear factor kappa B/c-Jun N-terminal kinase (NF-b/JNK) signalling pathway, thereby improving the antioxidant defence system and reducing oxidative stress and inflammatory responses

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Findings indicate that sustained and regular physical activity can enhance liver function by regulating oxidative stress, lipid metabolism, and inflammation (Vella and Cameron-Smith, 2010)

however, it is known that aggregation and accumulation of ubiquitylated protein inclusions in the cytosol of motor neurons are a neuropathological hallmark of ALS ( TARDBP mutations)