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The core principle of this design is to preserve the secondary structure of the functional peptide (eg, -helix, -sheet) to ensure biological activity while maintaining the intermolecular interactions of the assembled peptide

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Methods 25:402408 Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods

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Czesnikiwwicz-Guzik M, Konturek SJ, Loster B