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Immune priming of the tumor microenvironment by radiation

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analyzed the significantly elevated glutameta concentration in tumor tissues of tumor-bearing mice, which was approximately 27 times higher than that in adjacent tissues [175]

[46] did not estimate a sample size required for a study of this nature (a survey study). [48] In response, Schultz [49] stated that, given that calculating a studys appropriate sample size requires some foreknowledge of the size of the expected effect, the appropriate sample size could not have been calculated prior to initiation of the study