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Chemico Biol Interact 292:7683

10.1016/j.cell.2014.08.038 Cell 57 PetersonT

The ubiquitination of NRF2 may also influence drug resistance in OC [101]

Thus, overactive mTORC1 inhibits mitophagy, leading to the accumulation of dysfunctional mitochondria, which contributes to increased ROS production and reduced cellular energy efficiency