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However, the absence of FDA approval for any medical indication, limited large-scale trials, and variability in product formulations underscore the need for caution [10, 11]

" These peptide fragments might play a role in cellular signaling, particularly influencing fibroblasts, which are cells deemed critical for synthesizing new collagen fibers

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11.1% with placebo

You can also plug your own vial size and target dose into the dosage calculator to confirm the draw

One study covered in the review found that a topical containing Syn-Ake resulted in a 52% reduction in wrinkle size after 28 days of use.34 (As an interesting side note, you may have noticed that Syn-Ake kind of looks or sounds like the word snake. This is because the synthetic peptide Syn-Ake is an analog of a natural one called Waglerin-1, which is derived from the venom of the Southeast Asian temple viper.)34 As with Allies of Skin, much of the research behind the ingredients in The Ordinarys product is positive